反应详情

The title compound was prepared as described herein using 3-{[3-(aminomethyl)-2-chloro-6-fluorophenyl]oxy}-5-chlorobenzonitrile (40 mg, 0.129 mmol), 4-chloro-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxylic acid (35.6 mg, 0.129 mmol), EDC (29.6 mg, 0.154 mmol) and HOBT (29.5 mg, 0.193 mmol) in DMF (3.0 ml) to give the title compound as a white solid (43 mg, 76%). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.62 (1H, s) 7.40 (1H, dd, J=8.5, 5.4 Hz) 7.35 (2H, br. s.) 7.12-7.22 (2H, m) 7.00 (1H, s) 4.75 (2H, d). LCMS: m/z 439 (M+1).

1. customThe title compound was prepared