Hydrochloric Acid → HCID 68665125, compound

HRID 1875385Notes

Reaction equation

HRID 1875385 reaction equation
C([O:5][C:6](=[O:50])[C@@H:7]([NH:13][C:14]([O:16][CH2:17][C:18]([CH3:49])([CH3:48])[CH2:19][CH:20]1[CH2:22][CH:21]1[C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][C:32]=1[O:33][CH3:34])[N:29]=[C:28]([O:35][CH2:36][CH3:37])[CH:27]=[C:26]2[O:38][C@H:39]1[CH2:43][NH:42][C@H:41]([C:44]([O:46][CH3:47])=[O:45])[CH2:40]1)=[O:15])[CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)(C)(C)C.[ClH:51]>O1CCOCC1>[ClH:51].[ClH:51].[CH:8]1([C@H:7]([NH:13][C:14]([O:16][CH2:17][C:18]([CH3:48])([CH3:49])[CH2:19][CH:20]2[CH2:22][CH:21]2[C:23]2[CH:24]=[C:25]3[C:30](=[CH:31][C:32]=2[O:33][CH3:34])[N:29]=[C:28]([O:35][CH2:36][CH3:37])[CH:27]=[C:26]3[O:38][C@@H:39]2[CH2:40][C@@H:41]([C:44]([O:46][CH3:47])=[O:45])[NH:42][CH2:43]2)=[O:15])[C:6]([OH:50])=[O:5])[CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131730053HCID 131730053, compound

Product 1

HCID 68665125HCID 68665125, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of the product from Step 5 (25.2 g, 31.6 mmol) in 4.0 N HCl in dioxane (400 mL) was stirred for 6 hours. N2 was bubbled through the solution for 15 minutes, and the solvent was concentrated in vacuo to give 20.3 g of the title compound as a thick oil. LRMS ESI+ (M+H−2(HCl))+ 642.3, calcd for C34H48N3O9: 642.3.

Workup

  1. customN2 was bubbled through the solution for 15 minutes
  2. concentrationthe solvent was concentrated in vacuo

Sources & evidence

ORD record
ord-facccdce861149818a56c1daf0e39212
Source dataset
uspto-grants-2012_11
Patent number
US08309540B2

Reaction notes

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