反应详情

温度

65 °C

150 mg (0.50 mmol) of ethyl 3-(2-fluorobenzyl)imidazo[1,5-a]pyridine-1-carboxylate from example 7A are introduced into a mixture of 1 ml of methanol and 0.5 ml of THF, and 503 mg (10.1 mmol) of hydrazine hydrate are added. The mixture is heated firstly at 65° C. for 4 h and then at 90° C. for 10 h. It is then concentrated to dryness. The resulting crude product (157 mg, quantitative) is reacted without further purification.

1. additionare added
2. concentrationIt is then concentrated to dryness
3. customThe resulting crude product (157 mg, quantitative) is reacted without further purification