Methylamine → HCID 59543027, compound

HRID 1876319Notes

Reaction equation

HRID 1876319 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23]([OH:25])=O)[N:21]=1)=[CH:5]2.[CH3:26][NH2:27]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23]([NH:27][CH3:26])=[O:25])[N:21]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 6329MethylamineHCID 25196145[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]acetic acid

Product 1

HCID 59543027HCID 59543027, compoundYield 87%

Procedure

The compound (50 mg, 0.13 mmol) prepared in Example 27 and methylamine instead of morpholine were reacted according to the same procedure as Example 73 to give the title compound (45 mg, Yield 87%).

Sources & evidence

ORD record
ord-f231e5cb90624db7a4b2374c64a8560a
Source dataset
uspto-grants-2012_11
Patent number
US08309586B2

Reaction notes

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