反应详情

A mixture of 3-[4-(2-chloro-5-methoxypyrimidin-4-yl)-1H-pyrazol-1-yl]-3-cyclopropylpropanenitrile (from example 320 step 1, 250 mg, 0.00082 mol), 3-aminobenzoic acid (169 mg, 0.00123 mol), and p-toluenesulfonic acid (120 mg, 0.00070 mol) in dry 1,4-dioxane (5 mL, 0.07 mol) was refluxed overnight, then cooled to room temperature. The insoluble material was filtered off. The filtration was evaporated to dryness to give the crude product (330 mg, 99.14%). LCMS (M+H) 405.3.

1. temperaturewas refluxed overnight
2. filtrationThe insoluble material was filtered off
3. filtrationThe filtration
4. customwas evaporated to dryness