Ethyl formate → HCID 86655425, compound

HRID 1876909Notes

Reaction equation

HRID 1876909 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:13][CH2:12][S:11][C:10]2=[NH:14])=[CH:4][N:3]=1.[CH:15](OCC)=[O:16]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:13][CH2:12][S:11][C:10]2=[N:14][CH:15]=[O:16])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 8025Ethyl formate2×HCID 98593863-[(6-Chloro-3-pyridinyl)methyl]-2-thiazolidinimine

Product 1

HCID 86655425HCID 86655425, compound

Procedure

A mixture of 3-(2-Chloro-5-pyridinylmethyl)-2-iminothiazolidine (227 mg, 1.1 mmol) and 10 ml of ethyl formate was heated at the boiling point of ethyl formate for 5 hours with stirring. After distilling the excessive ethyl formate off followed by purification by a silica gel column chromatography, the resultant intended solid was washed with diethyl ether. Yield: 32 mg (13%). Melting point: 99-100° C.

Workup

  1. distillationAfter distilling the excessive ethyl formate
  2. customoff followed by purification by a silica gel column chromatography
  3. washwas washed with diethyl ether

Sources & evidence

ORD record
ord-db1f94d3905947dbbed3f1d7bfda6a1f
Source dataset
uspto-grants-2012_11
Patent number
US08309733B2

Reaction notes

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