反应详情

To a solution of ethyl 5-bromo-2-(1-hydroxyethyl)thiophene-3-carboxylate (11.0 g) synthesized above in trifluoroacetic acid (100 mL) was added dropwise triethylsilane (18.8 mL). After stirring at room temperature for 1 hr, the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:19, volume ratio) to give the title compound (9.67 g, 94%) as a pale-yellow oil.

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. customThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:19, volume ratio)