反应详情

The process is carried out as in stage 3 of Example 3, but using 84 mg of 2-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzonitrile, obtained according to stage 2 of Example 3, 83 mg of potassium carbonate and 300 mg of 3-amino-1-propanol in 0.67 ml of dimethyl sulphoxide. 0.4 ml of a 1M aqueous solution of sodium hydroxide, 0.4 ml of a 30% aqueous solution of hydrogen peroxide and 2 ml of ethanol are then added to the reaction medium. After treatment and purification as in stage 3 of Example 3, 85 mg of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(3-hydroxypropylamino)benzamide are thus obtained in the form a white solid, the characteristics of which are the following:

1. customobtained
2. customAfter treatment and purification as in stage 3 of Example 3, 85 mg of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(3-hydroxypropylamino)benzamide
3. customare thus obtained in the form a white solid