HCID 58239605, compound → HCID 58239595, compound

HRID 1877716Notes

Reaction equation

HRID 1877716 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[C:19]([C:21]#[C:22][CH2:23][CH2:24][OH:25])[CH:18]=[C:17]([C:26]#[C:27][CH2:28][CH2:29][OH:30])[CH:16]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>C1COCC1.[Pd]>[OH:25][CH2:24][CH2:23][CH2:22][CH2:21][C:19]1[CH:20]=[C:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=2)[CH:16]=[C:17]([CH2:26][CH2:27][CH2:28][CH2:29][OH:30])[CH:18]=1

Participants

4

Reactant 1

HCID 58239605HCID 58239605, compound

Product 1

HCID 58239595HCID 58239595, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

4-[4′-Benzyloxy-5-(4-hydroxybut-1-ynyl)biphenyl-3-yl]but-3-yn-1-ol is dissolved in THF and hydrogenated to completion on a palladium/activated carbon catalyst. The catalyst is filtered off, the filtrate is evaporated in vacuo, and the residue is filtered through silica gel with toluene/ethyl acetate (1:1).

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated in vacuo
  3. filtrationthe residue is filtered through silica gel with toluene/ethyl acetate (1:1)

Sources & evidence

ORD record
ord-00c31e0958ed40879b547a284e790ca1
Source dataset
uspto-grants-2012_11
Patent number
US08313669B2

Reaction notes

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