Hydroxyacetic acid--2-hydroxypropanoic acid (1/1) → HCID 137252526, compound

HRID 1877720Notes

Reaction equation

HRID 1877720 reaction equation
[CH3:1][CH:2]([OH:6])[C:3]([OH:5])=[O:4].[CH2:7]([OH:11])[C:8]([OH:10])=[O:9].[CH3:12][C@H:13]1[C@@:52]2([OH:54])[O:53][C@H:16]([CH2:17][C@H:18]([O:75][CH3:76])[C:19]([CH3:74])=[CH:20][CH:21]=[CH:22][CH:23]=[CH:24][C@@H:25]([CH3:73])[CH2:26][C@@H:27]([CH3:72])[C:28]([C@H:30]([O:70][CH3:71])[C@H:31]([OH:69])[C:32]([CH3:68])=[CH:33][C@@H:34]([CH3:67])[C:35]([CH2:37][C@@H:38]([C@@H:55]([CH2:57][C@H:58]3[CH2:63][C@@H:62]([O:64][CH3:65])[C@H:61]([OH:66])[CH2:60][CH2:59]3)[CH3:56])[O:39][C:40]([C@H:42]3[N:47]([C:48]([C:50]2=[O:51])=[O:49])[CH2:46][CH2:45][CH2:44][CH2:43]3)=[O:41])=[O:36])=[O:29])[CH2:15][CH2:14]1>>[CH3:12][C@H:13]1[C@@:52]2([OH:54])[O:53][C@H:16]([CH2:17][C@H:18]([O:75][CH3:76])[C:19]([CH3:74])=[CH:20][CH:21]=[CH:22][CH:23]=[CH:24][C@@H:25]([CH3:73])[CH2:26][C@@H:27]([CH3:72])[C:28]([C@H:30]([O:70][CH3:71])[C@H:31]([OH:69])[C:32]([CH3:68])=[CH:33][C@@H:34]([CH3:67])[C:35]([CH2:37][C@@H:38]([C@@H:55]([CH2:57][C@H:58]3[CH2:63][C@@H:62]([O:64][CH3:65])[C@H:61]([OH:66])[CH2:60][CH2:59]3)[CH3:56])[O:39][C:40]([C@H:42]3[N:47]([C:48]([C:50]2=[O:51])=[O:49])[CH2:46][CH2:45][CH2:44][CH2:43]3)=[O:41])=[O:36])=[O:29])[CH2:15][CH2:14]1.[CH3:1][CH:2]([OH:6])[C:3]([OH:5])=[O:4].[CH2:7]([OH:11])[C:8]([OH:10])=[O:9]

Participants

3

Reactant 2

HCID 36797Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)HCID 5284616Sirolimus

Product 1

HCID 137252526HCID 137252526, compound

Procedure

The preparation of the A/B syringe configuration was done as follows: to 1.2 mL female syringes approximately 980 mg of sterilized ATRIGEL® polymer solutions was added. Then, in 1.2 mL male syringes, approximately 20 mg of rapamycin was weighed. Prior to injection the two syringes were coupled and mixed 90 cycles to afford the 2.0 weight % formulation.

Workup

  1. customThe preparation of the A/B syringe configuration
  2. additionmixed 90 cycles
  3. customto afford the 2.0 weight % formulation

Sources & evidence

ORD record
ord-8c4680c3eb454046a4cbb89b6e83df96
Source dataset
uspto-grants-2012_11
Patent number
US08313763B2

Reaction notes

Loading…