Hydrochloric Acid → HCID 66878102, compound

HRID 1878381Notes

Reaction equation

HRID 1878381 reaction equation
[C:1]([NH:5][C:6]([C:8]1[CH:9]=[C:10]([CH:27]=[CH:28][CH:29]=1)[CH2:11][N:12]1[C@H:17]([CH3:18])[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][C@@H:13]1[CH3:26])=[O:7])([CH3:4])([CH3:3])[CH3:2].[ClH:30]>>[ClH:30].[C:1]([NH:5][C:6](=[O:7])[C:8]1[CH:29]=[CH:28][CH:27]=[C:10]([CH2:11][N:12]2[C@H:13]([CH3:26])[CH2:14][NH:15][CH2:16][C@@H:17]2[CH3:18])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 57917715HCID 57917715, compound

Product 1

HCID 66878102HCID 66878102, compound

Procedure

(3S,5R)-tert-Butyl 4-(3-(tert-butylcarbamoyl)benzyl)-3,5-dimethylpiperazine-1-carboxylate (0.07 g, 0.17 mmol) was treated with an ethanolic solution of hydrochloric acid (2 mL, 14.5 wt % hydrochloric acid in ethanol). The resultant mixture was stirred at room temperature for 2 hours. The mixture was concentrated under vacuum, azeotroped with dichloromethane (×2) and dried under vacuum to afford the title compound (0.052 g) as a white foamy solid. MS (ESI) m/z 304.4 [M+H]+

Workup

  1. concentrationThe mixture was concentrated under vacuum
  2. customazeotroped with dichloromethane (×2)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-8cbfe31db6864d438ddabb939e86906a
Source dataset
uspto-grants-2012_11
Patent number
US08314091B2

Reaction notes

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