Trifluoroacetic acid → HCID 66878628, compound

HRID 1878402Notes

Reaction equation

HRID 1878402 reaction equation
[C:1]1([NH:7][C:8](=[O:31])[NH:9][C:10]2[CH:30]=[CH:29][C:13]([C:14]([N:16]3[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]3)=[O:15])=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>ClCCl>[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[C:1]1([NH:7][C:8]([NH:9][C:10]2[CH:30]=[CH:29][C:13]([C:14]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)=[O:15])=[CH:12][CH:11]=2)=[O:31])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 46511620tert-Butyl 4-(4-(3-phenylureido)benzoyl)piperazine-1-carboxylate

Product 1

HCID 66878628HCID 66878628, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-(4-(3-phenylureido)benzoyl)piperazine-1-carboxylate (15.0 g, 35.34 mmol) was stirred with 50% trifluoroacetic acid in dichloromethane (200 ml) at room temperature for 1 hour. The reaction was concentrated under vacuum and then dryed overnight on high vacuum to afford the title compound (15.5 g). MS (ESI) m/z 325.0 [M+H]+

Workup

  1. concentrationThe reaction was concentrated under vacuum

Sources & evidence

ORD record
ord-c5e7648f60544a63a09a51399439cf83
Source dataset
uspto-grants-2012_11
Patent number
US08314091B2

Reaction notes

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