反应详情

To a stirred solution of bis(trichloromethyl) carbonate (0.989 mmol, 0.294 g) in dichloromethane (30 mL) was added (R)-3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-sec-butylbenzamide (2.91 mmol, 1.2 g) and N-ethyl-N-isopropylpropan-2-amine (6.40 mmol, 1.058 mL, 0.827 g) in dichloromethane (30 mL). The reaction mixture was stirred for 1 hour then 2,2-dimethylpropan-1-amine (3.49 mmol, 0.408 ml, 0.304 g) was added. After 2 hours stirring, the crude material was purified by acidic reverse phase LC/MS then by silica chromatography to give the title compound (25 mg).

1. stirringAfter 2 hours stirring
2. customthe crude material was purified by acidic reverse phase LC/MS