Trifluoroacetic acid → HCID 70999635, compound

HRID 1878551Notes

Reaction equation

HRID 1878551 reaction equation
FC(F)(F)C(O)=O.[N:8]1([C:14]2[N:19]3[N:20]=[C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:22]=[C:18]3[N:17]=[C:16]([NH:29][NH2:30])[CH:15]=2)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[C:31]([C:34]1[CH:35]=[C:36]([CH:39]=[CH:40][CH:41]=1)[CH:37]=O)([OH:33])=[O:32]>C(O)C>[C:31]([C:34]1[CH:35]=[C:36]([CH:39]=[CH:40][CH:41]=1)[CH:37]=[N:30][NH:29][C:16]1[CH:15]=[C:14]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:19]2[N:20]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:22]=[C:18]2[N:17]=1)([OH:33])=[O:32]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 120773-CarboxybenzaldehydeHCID 70867226HCID 70867226, compound

Product 1

HCID 70999635HCID 70999635, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

There was dissolved, in ethanol (2 mL), trifluoroacetic acid salt of (7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (20.3 mg, 0.0377 mM), then 3-carboxy-benzaldehyde (5.7 mg, 0.038 mM) was added to the solution and the mixture was stirred at room temperature for one hour. This reaction liquid was filtered and the resulting solid was washed with methanol to thus give the title compound (14.0 mg, yield: 84%).

Workup

  1. customThis reaction liquid
  2. filtrationwas filtered
  3. washthe resulting solid was washed with methanol

Sources & evidence

ORD record
ord-bc2d531147bf4d809e7cd534fd838239
Source dataset
uspto-grants-2012_11
Patent number
US08314098B2

Reaction notes

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