Acetic Acid → HCID 77967083, compound

HRID 1878569Notes

Reaction equation

HRID 1878569 reaction equation
[CH3:1][C:2]1[CH:18]=[C:5]2[N:6]=[C:7]([NH:16][NH2:17])[CH:8]=[C:9]([N:10]3[CH2:15][CH2:14][O:13][CH2:12][CH2:11]3)[N:4]2[N:3]=1.C(O)(=O)C.[CH3:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH:27]=O>C(O)C>[CH3:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH:27]=[N:17][NH:16][C:7]1[CH:8]=[C:9]([N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[N:4]2[N:3]=[C:2]([CH3:1])[CH:18]=[C:5]2[N:6]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 121053-MethylbenzaldehydeHCID 70999609HCID 70999609, compound

Product 1

HCID 77967083HCID 77967083, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

There was dissolved, in ethanol (2 mL), (2-methyl-7-morpholin-4-yl-pyrazolo-[1,5-a]pyrimidin-5-yl)-hydrazine (24.7 mg, 0.0995 mM), then acetic acid (5.0 μL, 0.087 mM) and 3-methyl-benzaldehyde (12.9 μL, 0.109 mM) were added to the solution and the resulting mixture was stirred at room temperature for 2 hours. This reaction liquid was filtered and the resulting solid was washed with methanol to thus give the title compound (29.6 mg, yield: 85%).

Workup

  1. customThis reaction liquid
  2. filtrationwas filtered
  3. washthe resulting solid was washed with methanol

Sources & evidence

ORD record
ord-f28679cb7aff4fabb4cbf72ecfa1778e
Source dataset
uspto-grants-2012_11
Patent number
US08314098B2

Reaction notes

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