2-Bromopropane → 4-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-isopropyl-piperidine

HRID 1878961Notes

Reaction equation

HRID 1878961 reaction equation
[F:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(=O)([O-])[O-].[K+].[K+].Br[CH:25]([CH3:27])[CH3:26]>C(#N)C>[F:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][CH2:16][N:15]([CH:25]([CH3:27])[CH3:26])[CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 574480384-[2-Fluoro-3-(methylsulfonyl)phenyl]piperidine

Product 1

HCID 675321424-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-isopropyl-piperidine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 4-[2-fluoro-3-(methylsulfonyl)-phenyl]-piperidine (0.02 g, 0.078 mmol), acetonitrile (2 ml), potassium carbonate (0.02 g, 0.14 mmol), 2-bromopropane (0.008 ml, 0.082 mmol). MS m/z (relative intensity, 70 eV) 299 (M+, 3), 285 (15), 284 (bp), 205 (6) 133 (4).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-eba291efc7ee4ee7a9b6400a7623fd2d
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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