Hydrochloric Acid → HCID 67533049, compound

HRID 1878971Notes

Reaction equation

HRID 1878971 reaction equation
C[O:2][C:3]1[C:8]([O:9][C:10]([F:13])([F:12])[F:11])=[CH:7][CH:6]=[CH:5][C:4]=1[CH:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH3:22])[CH2:16][CH2:15]1.Cl.N1C=CC=CC=1.Cl>>[CH2:20]([N:17]1[CH2:16][CH2:15][CH:14]([C:4]2[CH:5]=[CH:6][CH:7]=[C:8]([O:9][C:10]([F:11])([F:12])[F:13])[C:3]=2[OH:2])[CH2:19][CH2:18]1)[CH2:21][CH3:22]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 10176127Pyridinium chlorideHCID 57448049HCID 57448049, compound

Product 1

HCID 67533049HCID 67533049, compound

Procedure

Preparation according to Example 29: 4-[2-methoxy-3-(trifluoromethoxy)phenyl]-1-propylpiperidine (1.32 g, 4.16 mmol), pyridine hydrochloride (3 g). Yield: 0.7 g (55%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 203-205° C. MS m/z (relative intensity, 70 eV) 303 (M+, 11), 275 (15), 274 (bp), 145 (4), 117 (6).

Workup

  1. customPreparation
  2. customrecrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-441743e4ca76499c936c5a77500353d0
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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