Potassium Carbonate → HCID 67533216, compound

HRID 1879005Notes

Reaction equation

HRID 1879005 reaction equation
[F:1][C:2]([F:19])([F:18])[CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:6]=1[F:17])[OH:4].C(=O)([O-])[O-].[K+].[K+].Br[CH2:27][CH2:28][O:29][CH3:30]>C(#N)C>[F:19][C:2]([F:1])([F:18])[CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:12][CH2:13][N:14]([CH2:27][CH2:28][O:29][CH3:30])[CH2:15][CH2:16]2)[C:6]=1[F:17])[OH:4]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 57448056HCID 57448056, compound

Product 1

HCID 67533216HCID 67533216, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 2,2,2-trifluoro-1-(2-fluoro-3-piperidin-4-ylphenyl)ethanol (0.01 g), acetonitrile (2 ml), potassium carbonate (0.01 g) and 1-bromo-2-methoxyethane (0.01 g). MS m/z (rel. intensity, 70 eV) 335 (M+, 1), 291 (15), 290 (bp), 207 (4), 149 (7).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-bf9005fa29f84940ab72f25b516e4273
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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