Iodoethane → HCID 67533235, compound

HRID 1879006Notes

Reaction equation

HRID 1879006 reaction equation
[F:1][C:2]([F:19])([F:18])[CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:6]=1[F:17])[OH:4].C(=O)([O-])[O-].[K+].[K+].I[CH2:27][CH3:28]>C(#N)C>[CH2:27]([N:14]1[CH2:13][CH2:12][CH:11]([C:7]2[C:6]([F:17])=[C:5]([CH:3]([OH:4])[C:2]([F:1])([F:18])[F:19])[CH:10]=[CH:9][CH:8]=2)[CH2:16][CH2:15]1)[CH3:28]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 57448056HCID 57448056, compound

Product 1

HCID 67533235HCID 67533235, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 2,2,2-trifluoro-1-(2-fluoro-3-piperidin-4-ylphenyl)ethanol (0.01 g), acetonitrile (2 ml), potassium carbonate (0.01 g) and iodoethane (0.01 g). MS m/z (rel. intensity, 70 eV) 305 (M+, 17), 304 (13), 291 (15), 290 (bp), 149 (5).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-5eefacb5091f4e9b94bca4d19a733e01
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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