HCID 67532501, compound → HCID 67533000, compound

HRID 1879020Notes

Reaction equation

HRID 1879020 reaction equation
[F:1][C:2]1[C:3]([C:18]([F:21])([F:20])[F:19])=[C:4]([C:8]2(O)[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH3:16])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1>Cl>[F:1][C:2]1[C:3]([C:18]([F:21])([F:19])[F:20])=[C:4]([C:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH3:16])[CH2:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 67532501HCID 67532501, compound

Product 1

HCID 67533000HCID 67533000, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Preparation according to preparation 2: 4-[3-fluoro-2-(trifluoromethyl)phenyl]-1-propylpiperidin-4-ol (2.98 g, 9.8 mmol), hydrochloric acid (40 ml, cone). Yield: 2.37 g. MS m/z (rel. intensity, 70 eV) 305 (M+, 7), 277 (14), 276 (bp), 258 (57), 163 (7).

Workup

  1. customPreparation
  2. customaccording to preparation 2

Sources & evidence

ORD record
ord-41ad04da4235449eb8a42833aa4b5bfe
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

Loading…