Iodoethane → HCID 67533539, compound

HRID 1879036Notes

Reaction equation

HRID 1879036 reaction equation
[F:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[S:14]([N:17]([CH3:19])[CH3:18])(=[O:16])=[O:15].I[CH2:21][CH3:22].[BH4-].[Na+]>C(O)C>[CH2:21]([N:11]1[CH2:10][CH:9]=[C:8]([C:7]2[C:2]([F:1])=[C:3]([S:14]([N:17]([CH3:19])[CH3:18])(=[O:16])=[O:15])[CH:4]=[CH:5][CH:6]=2)[CH2:13][CH2:12]1)[CH3:22]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 4311764Sodium borohydrideHCID 57448067Benzenesulfonamide, 2-fluoro-N,N-dimethyl-3-(4-pyridinyl)-

Product 1

HCID 67533539HCID 67533539, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation according to preparation 6: 2-fluoro-N,N-dimethyl-3-pyridin-4-ylbenzene sulfonamide (0.59 g, 2.11 mmol), 1-iodoethane (3 ml), ethanol (40 ml), sodium borohydride (0.4 g, 10.5 mmol). Yield: 0.27 g. MS m/z (rel. intensity, 70 eV) 312 (M+, bp), 311 (33), 297 (93), 146 (36), 110 (32).

Workup

  1. customPreparation
  2. customaccording to preparation 6

Sources & evidence

ORD record
ord-9d0f0032567e478faf13f7c040b58464
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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