Trifluoroacetic acid → HCID 24799723, compound

HRID 1879288Notes

Reaction equation

HRID 1879288 reaction equation
Cl[C:2]1[N:7]=[C:6]2[NH:8][N:9]=[CH:10][C:5]2=[C:4]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([NH2:21])(=[O:20])=[O:19])=[CH:14][CH:13]=2)[N:3]=1.[NH:22]1[C:30]2[C:25](=[CH:26][C:27]([NH2:31])=[CH:28][CH:29]=2)[CH:24]=[N:23]1.C(O)(C(F)(F)F)=O>CS(C)=O>[NH:22]1[C:30]2[C:25](=[CH:26][C:27]([NH:31][C:2]3[N:7]=[C:6]4[NH:8][N:9]=[CH:10][C:5]4=[C:4]([NH:11][C:12]4[CH:17]=[CH:16][C:15]([S:18]([NH2:21])(=[O:20])=[O:19])=[CH:14][CH:13]=4)[N:3]=3)=[CH:28][CH:29]=2)[CH:24]=[N:23]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 880121H-Indazol-5-amineHCID 57619092HCID 57619092, compound

Product 1

HCID 24799723HCID 24799723, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
120 °C

Procedure

Compound 4A, 1H-indazol-5-ylamine Compound 5A and TFA (94 ul, 1.1 mmol) were mixed in dry DMSO (1 ml) and heated to 120° C. for 48 hours to provide Compound 12 (99% yield). 1HNMR (CD3OD) δ 8.5 (s, 1H), 8.12 (s, 2H), 7.9 (m, 2H), 7.7 (d, 2H), 7.5 (d, 2H); MS 536 (M+H+).

Sources & evidence

ORD record
ord-a684ee2726c34d8fab4e11ca6b938c1a
Source dataset
uspto-grants-2012_11
Patent number
US08314234B2

Reaction notes

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