反应详情

To the solution of mandelic acid amide in dichloromethane is added N-ethyldiisopropylamine (1.1 equivalents) at RT. Subsequently p-toluene sulfonic acid chloride (1.0 equivalent) is added keeping the temperature below 25° C. The reaction mixture is stirred at RT until a satisfactory conversion is reached and then washed with saturated sodium bicarbonate solution and water. After a solvent switch to ethyl acetate the solution is concentrated, cooled to −2° C. and the precipitate filtered. The crystals are washed with cooled ethyl acetate and dried in vacuo at 40° C.

1. customthe temperature below 25° C
2. washwashed with saturated sodium bicarbonate solution and water
3. concentrationAfter a solvent switch to ethyl acetate the solution is concentrated
4. temperaturecooled to −2° C.
5. filtrationthe precipitate filtered
6. washThe crystals are washed with cooled ethyl acetate
7. customdried in vacuo at 40° C.