huagongshe.com
HRID1879340

反应详情

EQUATION

反应方程式

HRID 1879340 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CCOC(=N)c1ccccc1.Cl
HCID79249

Ethyl iminobenzoate hydrochloride

C9H12ClNO

2 次

结构：CS(=O)(=O)c1ccc([C@@H](O)[C@H](N)CO)cc1
HCID6452441

(R(R*,R*))-2-Amino-1-(p-(methylsulphonyl)phenyl)propane-1,3-diol

C10H15NO4S

2 次

PRODUCTS

生成物

1
结构：CS(=O)(=O)c1ccc([C@H]2OC(c3ccccc3)=N[C@@H]2CO)cc1
HCID14760452

{(4R,5R)-5-[4-(Methanesulfonyl)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazol-4-yl}methanol

C17H17NO4S

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

(1R,2R)-2-amino-1-[4-(methylsulfonyl)phenyl]-1,3-propanediol (Compound V wherein R1 is methylsulfonyl) (about 10 g, 0.04077) is reacted at about 0° C. in a reaction vessel with benzenecarboximidic acid ethyl ester hydrochloride (Compound IV hydrochloride wherein R2 is phenyl and R4 is ethyl) (about 8.3 g, 0.0448 moles) in 1,2-dichloroethane (about 650 mL) containing triethylamine (about 4.1 g, 0.04077 moles). Next, water (about 500 mL) is added. The resulting solids are filtered, then dried to yield (4R,5R)-4,5-Dihydro-5-[4-(methylsulfonyl)phenyl]-2-phenyl-4-oxazolemethanol (Compound II wherein R1 is methylsulfonyl and R2 is phenyl).

WORKUP

后处理

  1. filtrationThe resulting solids are filtered
  2. customdried