Phosphorus oxychloride → 3-Chloro-5-phenyl-pyridazine-4-carbonitrile

HRID 1879596Notes

Reaction equation

HRID 1879596 reaction equation
O=[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[N:4][NH:3]1.P(Cl)(Cl)([Cl:18])=O>>[Cl:18][C:2]1[N:3]=[N:4][CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]=1[C:8]#[N:9]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 597350963-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile

Product 1

HCID 597350973-Chloro-5-phenyl-pyridazine-4-carbonitrile

Conditions

Temperature
100 °C

Procedure

3-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile (70 mg) was suspended in 1 mL phosphorous oxychloride and heated to 100° C. for 6 hours. The mixture was then cooled and poured onto ice. The resulting brown solid product was filtered and air dried and used in the next step without further purification.

Workup

  1. temperatureThe mixture was then cooled
  2. additionpoured onto ice
  3. filtrationThe resulting brown solid product was filtered
  4. customair dried
  5. customused in the next step without further purification

Sources & evidence

ORD record
ord-800015b3b78a43a9babce63e6add21b0
Source dataset
uspto-grants-2012_11
Patent number
US08318467B2

Reaction notes

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