反应详情

To a mixture of N-cyclopropyl-2-nitrobenzenesulfonamide (5.63 g), potassium carbonate (4.82 g) and N,N-dimethylformamide (60 mL), methyl iodide (2.17 mL) was added and stirred at room temperature for 6 hours. The reaction mixture was evaporated under reduced pressure, and the residue was diluted with water and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate, followed by distilling off the solvent under reduced pressure. The residue was purified by silica gel column chromatography (eluent; n-hexane:diethyl ether=1:0-1:1) to give N-cyclopropyl-N-methyl-2-nitrobenzenesulfonamide (5.35 g) as a brown solid.

1. additionwas added
2. customThe reaction mixture was evaporated under reduced pressure
3. additionthe residue was diluted with water
4. extractionextracted with ethyl acetate
5. washThe organic layer was washed with saturated aqueous sodium chloride
6. dry with materialdried over anhydrous magnesium sulfate
7. distillationby distilling off the solvent under reduced pressure
8. customThe residue was purified by silica gel column chromatography (eluent; n-hexane:diethyl ether=1:0-1:1)