HCID 58147973, compound → HCID 136184191, compound

HRID 1879944Notes

Reaction equation

HRID 1879944 reaction equation
C([O:8][C:9]1[C:14](=[O:15])[N:13]2[CH:16]=[C:17]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[CH:18]=[C:19]([N:20]3[CH2:24][CH2:23][N:22]([CH3:25])[C:21]3=[O:26])[C:12]2=[N:11][C:10]=1[C:33]1[S:34][C:35]([CH2:38][C:39]2[CH:44]=[CH:43][C:42]([F:45])=[C:41]([Cl:46])[CH:40]=2)=[CH:36][N:37]=1)C1C=CC=CC=1>FC(F)(F)C(O)=O>[Cl:46][C:41]1[CH:40]=[C:39]([CH:44]=[CH:43][C:42]=1[F:45])[CH2:38][C:35]1[S:34][C:33]([C:10]2[N:11]=[C:12]3[C:19]([N:20]4[CH2:24][CH2:23][N:22]([CH3:25])[C:21]4=[O:26])=[CH:18][C:17]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)=[CH:16][N:13]3[C:14](=[O:15])[C:9]=2[OH:8])=[N:37][CH:36]=1

Participants

3

Reactant 1

HCID 58147973HCID 58147973, compound

Product 1

HCID 136184191HCID 136184191, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 3-Benzyloxy-2-[5-(3-chloro-4-fluoro-benzyl)-thiazol-2-yl]-9-(3-methyl-2-oxo-imidazolidin-1-yl)-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one (50 mg, 0.076 mmol) in trifluoroacetic acid (1 ml) was refluxed for 3 h. Then trifluoroacetic acid was removed under reduced pressure and MeOH (3 ml) was added. The resulting precipitate was collected by filtration and washed with MeOH to give title compound (40 mg, 93%).

Workup

  1. customThen trifluoroacetic acid was removed under reduced pressure and MeOH (3 ml)
  2. additionwas added
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with MeOH

Sources & evidence

ORD record
ord-20158c8a5c504de1b95b153f6785f4a0
Source dataset
uspto-grants-2012_11
Patent number
US08318732B2

Reaction notes

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