HCID 57471974, compound → HCID 57471975, compound

HRID 1880312Notes

Reaction equation

HRID 1880312 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]1[N:14]=[C:13]([NH:15][C:16]2[CH:30]=[CH:29][C:19]([O:20][CH2:21][C:22]([O:24]C(C)(C)C)=[O:23])=[CH:18][CH:17]=2)[C:12]([C:31](=[O:33])[NH2:32])=[CH:11][N:10]=1>C(O)(C(F)(F)F)=O>[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]1[N:14]=[C:13]([NH:15][C:16]2[CH:30]=[CH:29][C:19]([O:20][CH2:21][C:22]([OH:24])=[O:23])=[CH:18][CH:17]=2)[C:12]([C:31](=[O:33])[NH2:32])=[CH:11][N:10]=1

Participants

3

Reactant 1

HCID 57471974HCID 57471974, compound

Product 1

HCID 57471975HCID 57471975, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl 2-(4-(2-((1R,2S)-2-aminocyclohexylamino)-5-carbamoylpyrimidin-4-ylamino)phenoxy)acetate racemate (180 mg, 0.395 mmol) in TFA (4 mL) was stirred at room temperature for 2 h. It was then concentrated in vacuo. The residue was purified by HPLC to give the titled compound (60 mg). MS 401.2 (M+H).

Workup

  1. concentrationIt was then concentrated in vacuo
  2. customThe residue was purified by HPLC

Sources & evidence

ORD record
ord-fea41fa19a4d45498b01b1b2676f78ca
Source dataset
uspto-grants-2012_11
Patent number
US08318755B2

Reaction notes

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