反应详情

温度

40 °C

To a solution of methyl 2-methyl-2H-indazole-5-carboxylate (210 mg, 1.10 mmol) in methanol (5 mL) was added 1.0 M LiOH (1.2 mL, 1.2 mmol). The mixture was agitated at 40° C. overnight. After cooling to room temperature, 1 N HCl (1.17 mL, 1.1 eq) was added. The solution was cooled and the solid was isolated by filtration. The solid was dried in a vacuum oven at 50° C. to provide the title compound (147 mg, 76%).

1. temperatureAfter cooling to room temperature
2. temperatureThe solution was cooled
3. customthe solid was isolated by filtration
4. customThe solid was dried in a vacuum oven at 50° C.