Lithium Hydroxide → HCID 178492734, compound

HRID 1880417Notes

Reaction equation

HRID 1880417 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]([O:15]CC)=[O:14])[CH:6]=[C:7]2[C:11]=1[NH:10][N:9]=[C:8]2[CH3:12].[Li+].[OH-]>CCO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]([OH:15])=[O:14])[CH:6]=[C:7]2[C:11]=1[NH:10][N:9]=[C:8]2[CH3:12]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 178469302HCID 178469302, compound

Product 1

HCID 178492734HCID 178492734, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 7-methoxy-3-methyl-1H-indazole-5-carboxylate (294 mg, 1.26 mmol) in EtOH (11 mL) was added 1 M LiOH (2.5 mL). The mixture was heated at reflux for 4 hours, cooled to room temperature and concentrated. The crude material was triturated with 1 N HCl, the solids were isolated by filtration and washed with water. The solid was air dried overnight to provide the title compound (235 mg, 91%).

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 hours
  3. concentrationconcentrated
  4. customThe crude material was triturated with 1 N HCl
  5. customthe solids were isolated by filtration
  6. washwashed with water
  7. customdried overnight

Sources & evidence

ORD record
ord-2782653a505d43d391ae4b92a5ecee99
Source dataset
uspto-grants-2012_11
Patent number
US08318762B2

Reaction notes

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