Hydrochloric Acid → HCID 67530865, compound

HRID 1880818Notes

Reaction equation

HRID 1880818 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][C@H:12]([N:15]([S:20]([C:23]1[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][CH:24]=1)(=[O:22])=[O:21])[CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:13][OH:14])(C)(C)C.Cl>CO>[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C@H:12]([N:15]([CH2:16][CH:17]([CH3:19])[CH3:18])[S:20]([C:23]1[CH:24]=[CH:25][C:26]([C:29]#[N:30])=[CH:27][CH:28]=1)(=[O:22])=[O:21])[CH2:13][OH:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57687747HCID 57687747, compound

Product 1

HCID 67530865HCID 67530865, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(S)-{5-[(4-cyano-benzenesulfonyl)-isobutyl-amino]-6-hydroxy-hexyl}-carbamic acid tert-butyl ester (5) (1.06 g) was dissolved in 50 mL MeOH. HCl (5-6 N in i-prOH, 30 mL) was added and the mixture was stirred overnight at RT. The mixture was evaporated to dryness and used as such in the next reaction.

Workup

  1. customThe mixture was evaporated to dryness
  2. customsuch in the next reaction

Sources & evidence

ORD record
ord-3ba22c5e85434291af45aef527c17cf7
Source dataset
uspto-grants-2012_11
Patent number
US08318779B2

Reaction notes

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