Water → Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoate

5-Bromo-2-aminothiazole (25 g, 96 mmol) in DMF (150 mL) was added K2CO3 (26.5 g, 192 mmol) and the mixture was purged with N2 for 5 min. The mixture was cooled to 0° C. on an ice bath before 3-mercaptopropionic acid ethyl ester (12.9 g, 96 mmol) was added dropwise over the course of 30 min. The reaction mixture was stirred for 16 hs before water (400 mL) was added. The aquous mixture was extracted with Et2O (1×500 mL, 2×250 mL). The combined organic phases was washed with saturated NH4Cl (3×150 mL), dried (MgSO4). The solvent was removed in vacuo to give a dark residue which was purified by column chromatography (SiO2, EtOAc-heptane (1:1)). The solvent was removed in vacuo to give 11 g (49%) of the desired compound.

1. customthe mixture was purged with N2 for 5 min
2. additionwas added dropwise over the course of 30 min
3. additionwas added
4. extractionThe aquous mixture was extracted with Et2O (1×500 mL, 2×250 mL)
5. washThe combined organic phases was washed with saturated NH4Cl (3×150 mL)
6. dry with materialdried (MgSO4)
7. customThe solvent was removed in vacuo
8. customto give a dark residue which
9. customwas purified by column chromatography (SiO2, EtOAc-heptane (1:1))
10. customThe solvent was removed in vacuo

ORD record

ord-ff6c898c3ceb4e20a65f7f3bcee452b7

Source dataset

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08318778B2