1,1'-Carbonyldiimidazole → HCID 86639124, compound

HRID 1881116Notes

Reaction equation

HRID 1881116 reaction equation
[CH3:1][O:2][C:3](=[O:12])[CH2:4][S:5][C:6]1[S:10][C:9]([NH2:11])=[N:8][CH:7]=1.C1N=CN([C:18](N2C=NC=C2)=[O:19])C=1.[CH3:25][CH:26]1[CH2:31][CH2:30][CH:29]([NH:32][CH2:33][C:34]([CH3:42])([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH3:35])[CH2:28][CH2:27]1>C(Cl)Cl.CN(C1C=CN=CC=1)C>[CH3:1][O:2][C:3](=[O:12])[CH2:4][S:5][C:6]1[S:10][C:9]([NH:11][C:18]([N:32]([CH:29]2[CH2:30][CH2:31][CH:26]([CH3:25])[CH2:27][CH2:28]2)[CH2:33][C:34]([CH3:42])([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH3:35])=[O:19])=[N:8][CH:7]=1

Participants

6

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 24704801Methyl 2-[(2-amino-5-thiazolyl)thio]acetateHCID 54886392HCID 54886392, compound

Product 1

HCID 86639124HCID 86639124, compoundYield 36.1%

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

To a mixture of (2-amino-thiazol-5-ylsulfanyl)-acetic acid methyl ester (416 mg, 2.04 mmol) in CH2Cl2 (30 mL) was added CDI (496 mg, 3.06 mmol) and DMAP (25 mg, 0.21 mmol) at room temperature. The reaction mixture was stirred at rt for 1.5 h, then (4-methyl-cyclohexyl)-(2-methyl-2-phenyl-propyl)-amine (500 mg, 2.04 mmol) was added. The mixture was stirred for 16 h at room temperature. The solvent was removed at reduced pressure and the residue was purified by preparative HPLC to give {2-[3-(4-methyl-cyclohexyl)-3-(2-methyl -2-phenyl-propyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid methyl ester (350 mg).

Workup

  1. stirringThe mixture was stirred for 16 h at room temperature
  2. customThe solvent was removed at reduced pressure
  3. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-7b0b67b596434f5598547dfef5a5664e
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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