Morpholine → HCID 67094356, compound

HRID 1881155Notes

Reaction equation

HRID 1881155 reaction equation
C([O:4][C:5]1[CH:13]=[C:12]2[C:8]([C:9](=[O:21])[N:10]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[CH2:11]2)=[CH:7][C:6]=1[O:22][C:23](=[O:25])[CH3:24])(=O)C.N1CCOCC1>CN(C)C=O>[Cl:20][C:17]1[CH:16]=[CH:15][C:14]([N:10]2[C:9](=[O:21])[C:8]3[C:12](=[CH:13][C:5]([OH:4])=[C:6]([O:22][C:23](=[O:25])[CH3:24])[CH:7]=3)[CH2:11]2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 67094263HCID 67094263, compound

Product 1

HCID 67094356HCID 67094356, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of acetic acid 6-acetoxy-2-(4-chloro-phenyl)-3-oxo-2,3-dihydro-1H-isoindol-5-yl ester (0.5 g) in dry N,N-dimethylformamide (15 ml) was treated with morpholine (0.13 ml) at 0-5° C. and stirred then for an hour at room temperature. The reaction was poured into ice water and filtered.

Workup

  1. waitfor an hour at room temperature
  2. filtrationfiltered

Sources & evidence

ORD record
ord-46e8a9b686624383bc1cf6f0b75d059a
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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