HCID 67094292, compound → 2-(4-Chlorophenyl)-5,6-dihydroxy-4-nitro-2,3-dihydro-1H-isoindol-1-one

HRID 1881156Notes

Reaction equation

HRID 1881156 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16](=[O:17])[C:15]3[C:10](=[C:11]([N+:23]([O-:25])=[O:24])[C:12]([OH:22])=[C:13]([O:18]C(=O)C)[CH:14]=3)[CH2:9]2)=[CH:4][CH:3]=1>CO.Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:9][C:10]3[C:15](=[CH:14][C:13]([OH:18])=[C:12]([OH:22])[C:11]=3[N+:23]([O-:25])=[O:24])[C:16]2=[O:17])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 67094292HCID 67094292, compound

Product 1

HCID 159828402-(4-Chlorophenyl)-5,6-dihydroxy-4-nitro-2,3-dihydro-1H-isoindol-1-one

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 887MethanolSolvent

Procedure

Acetic acid 2-(4-chloro-phenyl)-6-hydroxy-7-nitro-3-oxo-2,3-dihydro-1H-isoindol-5-yl ester (0.24 g raw material) was refluxed in methanol (15 ml) with three drops of concentrated hydrochloric acid for six hours. The reaction mixture was cooled and filtered.

Workup

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-d0368d073e85492f8add1b71dbe63dea
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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