Nitric Acid → HCID 67094379, compound

HRID 1881180Notes

Reaction equation

HRID 1881180 reaction equation
[OH:1][C:2]1[C:3]([O:14][CH3:15])=[CH:4][C:5]2[CH:9]=[C:8]([C:10]([OH:12])=[O:11])[S:7][C:6]=2[CH:13]=1.[N+:16]([O-])([OH:18])=[O:17]>C(OCC)(=O)C.ClCCl>[OH:1][C:2]1[C:3]([O:14][CH3:15])=[CH:4][C:5]2[CH:9]=[C:8]([C:10]([OH:12])=[O:11])[S:7][C:6]=2[C:13]=1[N+:16]([O-:18])=[O:17]

Participants

5

Reactant 2

HCID 944Nitric AcidHCID 212834786-Hydroxy-5-methoxybenzo[b]thiophene-2-carboxylic acid

Product 1

HCID 67094379HCID 67094379, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

6-Hydroxy-5-methoxy-benzo[b]thiophene-2-carboxylic acid (3.2 g) was dissolved in ethyl acetate (200 ml) and a solution of nitric acid in dichloromethane (2M, 7.7 ml) was gradually added at 0° C. into. The solution was stirred 30 min at room temperature and then it was poured into ice-cold water and filtered. The solid was washed with ethyl acetate and dried under vacuum.

Workup

  1. additionit was poured into ice-cold water
  2. filtrationfiltered
  3. washThe solid was washed with ethyl acetate
  4. customdried under vacuum

Sources & evidence

ORD record
ord-41ef2712c1854e6ea83185f5703d59ea
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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