Ethyl Acetate → HCID 67094182, compound

HRID 1881197Notes

Reaction equation

HRID 1881197 reaction equation
Cl[S:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[C:9]([O:14][CH3:15])=[CH:8][C:4]=1[C:5](Cl)=[O:6].Cl.[CH3:17][NH2:18].C(OCC)(=O)C>N1C=CC=CC=1>[CH3:15][O:14][C:9]1[C:10]([O:12][CH3:13])=[CH:11][C:3]2[S:2][N:18]([CH3:17])[C:5](=[O:6])[C:4]=2[CH:8]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 6364545Methylamine hydrochlorideHCID 20349384HCID 20349384, compound

Product 1

HCID 67094182HCID 67094182, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Chlorosulfenyl-4,5-dimethoxybenzoyl chloride (5.0 g) was dissolved in pyridine (30 ml) and methylamine hydrochloride (6.0 g) was added. The mixture was stirred at room temperature for 2 days. Ethyl acetate was added and the mixture was washed with 1 N HCl and water. Ethyl acetate was dried with Na2SO4 and evaporated to dryness. The crude product was purified by flash chromatography eluting with heptane-ethyl acetate (1:9).

Workup

  1. washthe mixture was washed with 1 N HCl and water
  2. dry with materialEthyl acetate was dried with Na2SO4
  3. customevaporated to dryness
  4. customThe crude product was purified by flash chromatography
  5. washeluting with heptane-ethyl acetate (1:9)

Sources & evidence

ORD record
ord-c6a621bb3d1f455bb0b19e8db26fda8d
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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