Water → HCID 67094378, compound

HRID 1881232Notes

Reaction equation

HRID 1881232 reaction equation
Br[CH2:2][C:3]1[C:4]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[CH:16][C:5]=2[S:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)=[O:9].[Cu][C:25]#[N:26].O>CN(C)C=O>[CH3:21][O:20][C:18]1[C:17]([O:22][CH3:23])=[CH:16][C:5]2[S:6][C:7]([C:8]([N:10]3[CH2:15][CH2:14][O:13][CH2:12][CH2:11]3)=[O:9])=[C:3]([CH3:2])[C:4]=2[C:19]=1[C:25]#[N:26]

Participants

5

Reactant 3

HCID 962WaterHCID 67094164HCID 67094164, compoundHCID 178418546HCID 178418546, compound

Product 1

HCID 67094378HCID 67094378, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

(4-Bromo-5,6-dimethoxy-3-methyl-benzo[b]thiophen-2-yl)-morpholin-4-yl-methanone (0.42 g) from Example 33 and copper(I) cyanide (2.0 g) in N,N-dimethylformamide (8 ml) were irradiated in a microwave oven at 150° C. for 1.5 hours. To the mixture water was added and the product was extracted into ethyl acetate. Ethyl acetate was dried and evaporated to dryness.

Workup

  1. extractionthe product was extracted into ethyl acetate
  2. dry with materialEthyl acetate was dried
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-20a112c1eef5458a83f1c3c6c804e4a0
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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