Water → HCID 59707341, compound

HRID 1881377Notes

Reaction equation

HRID 1881377 reaction equation
[Si:1]([O:8][CH2:9][CH2:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[C:13]([OH:19])[CH:12]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH2:20](Cl)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(=O)([O-])[O-].[K+].[K+].O>C(OCC)(=O)C>[CH2:20]([O:19][C:13]1[CH:12]=[C:11]([CH2:10][CH2:9][O:8][Si:1]([C:4]([CH3:6])([CH3:7])[CH3:5])([CH3:3])[CH3:2])[CH:18]=[CH:17][C:14]=1[CH:15]=[O:16])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 59707354HCID 59707354, compound

Product 1

HCID 59707341HCID 59707341, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A combination of (2) (14 g, 0.050 mol), benzyl chloride (6.3 mL, 0.055 mol) and potassium carbonate (20.7 g, 0.15 mol) was heated to 100° C. for 3 h. After cooling to room temperature, water (200 mL) and ethyl acetate (400 mL) were added; the organic layer was separated and washed with water (5×200 mL), dried over MgSO4, filtered and evaporated to dryness under reduced pressure to produce the crude product as a yellow oil. This was used without further purification in the next step.

Workup

  1. customthe organic layer was separated
  2. washwashed with water (5×200 mL)
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-5ef7e9e534b940ceb55b6ee01b39cea0
Source dataset
uspto-grants-2012_11
Patent number
US08318790B2

Reaction notes

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