Acrylic Acid → HCID 178418321, compound

HRID 1881383Notes

Reaction equation

HRID 1881383 reaction equation
C=CC(O)=O.C(O)C(N)(CO)CO.Cl.COC(C1C=CC(O)=CC=1)=O.[CH:26]1[N:30]([CH2:31][O:32][CH:33]([CH2:36][OH:37])[CH2:34][OH:35])[C:29]2[N:38]=[C:39]([NH2:43])[N:40]=[C:41]([O-:42])[C:28]=2[N:27]=1.[Na+]>>[CH:26]1[N:30]([CH2:31][O:32][CH:33]([CH2:36][OH:37])[CH2:34][OH:35])[C:29]2[N:38]=[C:39]([NH2:43])[N:40]=[C:41]([OH:42])[C:28]=2[N:27]=1

Participants

5

Reactant 4

HCID 6581Acrylic AcidHCID 7456MethylparabenHCID 93573Tromethamine hydrochlorideHCID 23700083Ganciclovir Sodium

Product 1

HCID 178418321HCID 178418321, compoundYield 2%

Procedure

The Carbopol 934P and Poloxamer 407 (BASF Corp.) are first suspended in the TRIS HCl buffer (0.1 M) and the components are mixed under agitation overnight at 4° C. to ensure complete dissolution. The methylparaben is added and further stirring allowed until complete dissolution is observed. Ganciclovir sodium is mixed in while maintaining stirring to produce a 2.0% ganciclovir mucoadhesive, thermoreversible gel formulation. The mixture is maintained below room temperature until use.

Workup

  1. additionthe components are mixed under agitation overnight at 4° C.
  2. dissolutiondissolution
  3. dissolutionallowed until complete dissolution
  4. temperaturewhile maintaining
  5. stirringstirring

Sources & evidence

ORD record
ord-1a1fef6fef864a0ead18a22df91bc84a
Source dataset
uspto-grants-2012_11
Patent number
US08318817B2

Reaction notes

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