Triethylamine → 4-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

HRID 1881393Notes

Reaction equation

HRID 1881393 reaction equation
[CH3:1][C:2]([CH3:10])([CH3:9])[CH2:3][C:4]1[NH:8][CH:7]=[N:6][CH:5]=1.[CH3:11][N:12]([CH3:17])[S:13](Cl)(=[O:15])=[O:14].CCN(CC)CC>C(Cl)Cl.CN(C1C=CN=CC=1)C>[CH3:1][C:2]([CH3:10])([CH3:9])[CH2:3][C:4]1[N:8]=[CH:7][N:6]([S:13]([N:12]([CH3:17])[CH3:11])(=[O:15])=[O:14])[CH:5]=1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 83372Dimethylsulphamoyl chlorideHCID 20361665HCID 20361665, compound

Product 1

HCID 591403964-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-(2,2-dimethylpropyl)-1H-imidazole, dimethylsulfamoyl chloride (25 mL), Et3N (45 mL) in CH2Cl2 (300 mL) was added DMAP (0.8 g). The reaction mixture was refluxed overnight. The solvent was concentrated and the residue was purified by silica gel chromatography to give the title compound as a white solid.

Workup

  1. temperatureThe reaction mixture was refluxed overnight
  2. concentrationThe solvent was concentrated
  3. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-68bb87a40c404efbabeb9608ceb89346
Source dataset
uspto-grants-2012_11
Patent number
US08318767B2

Reaction notes

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