Hydrochloric Acid → HCID 66705654, compound

HRID 1881416Notes

Reaction equation

HRID 1881416 reaction equation
[ClH:1].[CH3:2][C:3]([CH3:32])([CH3:31])[CH2:4][C:5]1[N:6]=[C:7]([CH:16]([F:30])[CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=3)=[CH:20][CH:19]=2)[N:8](S(N(C)C)(=O)=O)[CH:9]=1>CO>[Cl-:1].[Cl-:1].[CH3:2][C:3]([CH3:32])([CH3:31])[CH2:4][C:5]1[N:6]=[C:7]([CH:16]([F:30])[CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][NH+:25]=3)=[CH:20][CH:19]=2)[NH2+:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 667054274-(2,2-dimethylpropyl)-2-[1-fluoro-2-(4-pyridin-2-ylphenyl)ethyl]-N,N-dimethyl-1H-imidazole-1-sulfonamide

Product 1

HCID 66705654HCID 66705654, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

Hydrogen chloride (4 M in 1,4-dioxane) (1 mL, 4 mmol) was added to a solution of 4-(2,2-dimethylpropyl)-2-[1-fluoro-2-(4-pyridin-2-ylphenyl)ethyl]-N,N-dimethyl-1H-imidazole-1-sulfonamide in methanol (1 mL). After stirring at 70° C. for 1 h, volatiles were removed to afford the title compound. (M+H) found: 338.

Workup

  1. customvolatiles were removed

Sources & evidence

ORD record
ord-935edd52b5ad4a9da03c27969343b10c
Source dataset
uspto-grants-2012_11
Patent number
US08318767B2

Reaction notes

Loading…