Lithium Hydroxide → HCID 57904137, compound

HRID 1881692Notes

Reaction equation

HRID 1881692 reaction equation
C[O:2][C:3](=[O:24])[CH2:4][CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH2:10][CH2:9][N:8]1[S:13]([C:16]1[C:21]([CH3:22])=[CH:20][CH:19]=[CH:18][C:17]=1[Cl:23])(=[O:15])=[O:14].[OH-].[Li+]>O.CO>[Cl:23][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([CH3:22])[C:16]=1[S:13]([N:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH:7]1[CH2:6][CH2:5][CH2:4][C:3]([OH:24])=[O:2])(=[O:14])=[O:15]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 57904254HCID 57904254, compound

Product 1

HCID 57904137HCID 57904137, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

4-(1-(2-Chloro-6-methylphenylsulfonyl)piperidin-2-yl)butanoic acid methyl ester (2.7 g, 7.3 mmol, 1 eq.) was dissolved in water (20 ml) and methanol (30 ml). Lithium hydroxide (0.87 g, 36.5 mmol, 5 eq.) was added, while stirring. The mixture was stirred at room temperature for 24 h.

Workup

  1. stirringThe mixture was stirred at room temperature for 24 h.

Sources & evidence

ORD record
ord-8721d5aaf714412ead194404ce2f1cd6
Source dataset
uspto-grants-2012_11
Patent number
US08318769B2

Reaction notes

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