Dimethylamine → 5-(Dimethylamino)-2-nitrobenzoic acid

HRID 1882186Notes

Reaction equation

HRID 1882186 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:14][NH:15][CH3:16]>>[CH3:14][N:15]([CH3:16])[C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 172865-Chloro-2-nitrobenzoic acid

Product 1

HCID 127157935-(Dimethylamino)-2-nitrobenzoic acid

Procedure

Concretely, 5-chloro-2-nitrobenzoic acid is dissolved in a dimethylamine aqueous solution and heated to produce 5-dimethylamino-2-nitrobenzoic acid. Hydrochloric acid is added to the reaction solution to precipitate out the product as a solid material. The solid material is separated to obtain 5-dimethylamno-2-nitrobenzoic acid almost quantitatively.

Workup

  1. temperatureheated

Sources & evidence

ORD record
ord-d51104c16ad949ca8411ee3dabdfe32d
Source dataset
uspto-grants-2012_11
Patent number
US08318975B2

Reaction notes

Loading…