反应详情

To a solution of Compound 249 (610 mg, 1.2 mmol) in dry DMF (3 mL) was added NaH (60 mg, 1.51 mmol) at 0° C. and the mixture was stirred for 20 min. To this ice cold reaction mixture was added MeI (0.72 ml, 1.44 mmol, 2 M solution) and stirred for another 30 min. at 0° C. Slowly the temperature was raised to room temperature and stirred for an additional hour. Reaction was quenched with water and extracted with ether, washed with brine, dried over Na2SO4 and finally purified flash chromatography to furnish Compound 250 (468 mg, 75%).

1. stirringstirred for another 30 min. at 0° C
2. stirringstirred for an additional hour
3. customReaction
4. customwas quenched with water
5. extractionextracted with ether
6. washwashed with brine
7. dry with materialdried over Na2SO4 and finally purified flash chromatography