Hydrochloric Acid → HCID 66630488, compound

HRID 1882630Notes

Reaction equation

HRID 1882630 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][O:10][C:11]2[N:19]=[C:18]3[C:14]([N:15]=[CH:16][N:17]3[C@H:20]3[C@@H:24]4[O:25]C(C)(C)[O:27][C@@H:23]4[C@@H:22]([NH:30][C:31](=[O:34])[CH2:32][CH3:33])[CH2:21]3)=[C:13]([NH:35][CH2:36][CH:37]([C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)[C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[N:12]=2)=[CH:4][CH:3]=1.Cl>C1COCC1.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][O:10][C:11]2[N:19]=[C:18]3[C:14]([N:15]=[CH:16][N:17]3[C@@H:20]3[CH2:21][C@H:22]([NH:30][C:31](=[O:34])[CH2:32][CH3:33])[C@@H:23]([OH:27])[C@H:24]3[OH:25])=[C:13]([NH:35][CH2:36][CH:37]([C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)[C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[N:12]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66630814HCID 66630814, compound

Product 1

HCID 66630488HCID 66630488, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

The title compound is prepared by dissolving N-{(3aR,4S,6R,6aS)-6-[2-[2-(4-Chloro-phenyl)-ethoxy]-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl}-propionamide (Example 235, Step 2) in THF, adding an equal volume of 1.0M hydrochloric acid, and stirring at room temperature for 48 hours, before diluting with water, and extracting into ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and the volatile components removed under reduced pressure, to yield the title compound.

Workup

  1. customThe title compound is prepared
  2. extractionextracting into ethyl acetate
  3. dry with materialThe organic phase is dried over magnesium sulfate
  4. filtrationfiltered
  5. customthe volatile components removed under reduced pressure

Sources & evidence

ORD record
ord-afaabd967817470d80ecf4910eb6ae96
Source dataset
uspto-grants-2012_11
Patent number
US08318750B2

Reaction notes

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