Hydrochloric Acid → HCID 69886777, compound

HRID 1883094Notes

Reaction equation

HRID 1883094 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[CH:13]=[CH:12][C:11](C(=O)C)=[CH:10][CH:9]=1.[C:17](=[O:20])([O-])[O-].[NH4+:21].[NH4+:22].[C-:23]#N.[K+].Cl.[CH2:27]([OH:29])[CH3:28]>>[CH3:23][C@@:28]1([C:11]2[CH:10]=[CH:9][C:8]([O:7][C@H:2]3[CH2:3][CH2:4][CH2:5][CH2:6][O:1]3)=[CH:13][CH:12]=2)[C:27](=[O:29])[NH:22][C:17](=[O:20])[NH:21]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 9032Potassium CyanideHCID 517111Ammonium CarbonateHCID 113903814'-Tetrahydropyranyloxy-acetophenone

Product 1

HCID 69886777HCID 69886777, compoundYield 65%

Conditions

Temperature
55 °C

Procedure

11.01 g (50 mmol) of 10.1 and 42.3 g (440 mmol) of ammonium carbonate were suspended in 200 ml of 50% strength ethanol. 4.23 g (65 mmol) of potassium cyanide were added thereto. The mixture was stirred at 50 to 60° C. for 5 hours. After a short time, a clear solution was formed. The mixture was allowed to stand at room temperature overnight and stirring was then continued at 60° C. for 6 hours. Using 6 N HCl, the pH was adjusted to 6.3 and the mixture was stirred with ice-cooling for 2 h. The precipitate was filtered off with suction, washed with water and dried over phosphorus pentoxide in a desiccator. 9.5 g (65%) of 10.2 were obtained.

Workup

  1. customAfter a short time, a clear solution was formed
  2. waitto stand at room temperature overnight
  3. stirringstirring
  4. waitwas then continued at 60° C. for 6 hours
  5. stirringthe mixture was stirred with ice-
  6. temperaturecooling for 2 h
  7. filtrationThe precipitate was filtered off with suction
  8. washwashed with water
  9. dry with materialdried over phosphorus pentoxide in a desiccator

Sources & evidence

ORD record
ord-20a2a4a7aec34f1fb2e118546033fe66
Source dataset
uspto-grants-2004_07
Patent number
US06759424B2

Reaction notes

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