Semicarbazide hydrochloride → HCID 86591899, compound

HRID 1883158Notes

Reaction equation

HRID 1883158 reaction equation
[C:1]([CH2:3][NH:4][C:5]([C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH:13][C:14]([C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][CH:21]=[CH:20][C:19]=2[C:25](=O)[CH3:26])=[O:15])=[O:6])#[N:2].C([O-])(=O)C.[K+].Cl.[NH2:34][NH:35][C:36]([NH2:38])=[O:37]>CO>[C:1]([CH2:3][NH:4][C:5]([C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH:13][C:14]([C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][CH:21]=[CH:20][C:19]=2[C:25](=[N:34][NH:35][C:36](=[O:37])[NH2:38])[CH3:26])=[O:15])=[O:6])#[N:2]

Participants

5

Reactant 3

HCID 11236Semicarbazide hydrochlorideHCID 517044Potassium AcetateHCID 20740262HCID 20740262, compound

Product 1

HCID 86591899HCID 86591899, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7-Acetyl-1H-indole-2-carboxylic acid [(1S,2R)-2-(cyanomethylcarbamoyl)-cyclohexyl]-amide was reacted with potassium acetate and semicarbazide hydrochloride in methanol and purified by preparative TLC plate to yield 7-[1-(carbamoyl-hydrazono)-ethyl]-1H-indole-2-carboxylic acid [(1S,2R)-2-(cyanomethylcarbamoyl)cyclohexyl]-amide MS: 367 (M+H+).

Workup

  1. custompurified by preparative TLC plate

Sources & evidence

ORD record
ord-3e89db3ec1f441bdb11fe5f064973dd0
Source dataset
uspto-grants-2004_07
Patent number
US06759428B2

Reaction notes

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