Tetrahydrofuran → HCID 13613762, compound

HRID 1883194Notes

Reaction equation

HRID 1883194 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.CC[N:10]([CH2:13]C)CC.[O:15]=[S:16](Cl)Cl.[CH2:19]1[CH2:23][O:22][CH2:21][CH2:20]1>>[S:16]([O:22][C:23]1[CH:19]=[CH:20][CH:21]=[CH:13][N:10]=1)([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1)=[O:15]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 178516071HCID 178516071, compound

Product 1

HCID 13613762HCID 13613762, compoundYield 91%

Procedure

Under nitrogen atmosphere, to a solution of 2-hydroxypyridine (2.66 g) and NEt3 (4.05 mL) in THF (80 mL) was added dropwise SOCl2 (1.05 mL) under ice-cooling, and the mixture was stirred for one hour. The mixture was filtered, and the solvent was evaporated under reduced pressure to give di-2-pyridyl sulfite (3.02 g, 91%).

Workup

  1. temperaturecooling
  2. filtrationThe mixture was filtered
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-ed8756d63503458f92f3e61c0204d07a
Source dataset
uspto-grants-2004_07
Patent number
US06759429B2

Reaction notes

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