反应详情

A mixture of 2-bromo-4,6-diisopropyl-phenol (Intermediate 2, 14.5 g, 56 mmol), 1-iodopropane (16.5 mL, 169 mmol), and K2CO3 (38.6 g, 280 mmol) in acetone (100 mL) was stirred at room temperature for 64 h. The solvent was removed in vacuo, and the residue was taken up in CHCl3 and filtered. The filtrate was concentrated in vacuo and the crude product was purified by flash column chromatography on silica gel (hexanes) to yield the title compound as a colorless oil (16.0 g, 95%).

1. customThe solvent was removed in vacuo
2. filtrationfiltered
3. concentrationThe filtrate was concentrated in vacuo
4. customthe crude product was purified by flash column chromatography on silica gel (hexanes)